/ /

  • linkedin
  • Increase Font
  • Sharebar

    Managing acute heavy menstrual bleeding

    Recommendations for hormonal regimens to halt blood loss in the outpatient

    Illustration by Alex Baker, DNA Illustrations, Inc.
    Dr. Nelson is a professor in the Department of Obstetrics and Gynecology at the David Geffen School of Medicine at the University of California, Los Angeles.

    She reports receiving salary/honoraria from Actavis, Bayer, Merk, Pfizer, and Teva; consulting fees from Agile, Bayer, Merk, Pfizer, and Teva; and grants from Bayer, Merk, Pfizer, and Teva.

     

    A 32-year-old G4P2022 with a body mass index (BMI) of 32 kg/m2 presents with a history of heavy and prolonged bleeding for 10 days. She is slightly fatigued but denies any dizziness or shortness of breath. She reports that she has soaked 12 thick sanitary napkins in the last 24 hours. Normally her menses occur every 28 to 32 days and last for 4 days with moderate flow (3–4 pads per day). She relies on her husband’s vasectomy for birth control. She is slightly tachycardic, but has no orthostatic changes in her vital signs. Her hemoglobin is 9.1. Pelvic exam reveals moderate blood flow from her cervical os. She has a slightly enlarged uterus with no signs of infection. Her urine pregnancy test is negative.

     

    Acute abnormal uterine bleeding is not an uncommon challenge facing practitioners who care for women. The new International Federation of Gynecology and Obstetrics (FIGO) classification system defines it as an episode of heavy bleeding that, in the opinion of the clinician, is of sufficient quantity to require immediate intervention to prevent future blood loss.1 The evaluation that a woman with acute abnormal uterine bleeding needs has been outlined in 2 recent American College of Obstetricians and Gynecologists (ACOG) bulletins and one ACOG Committee Opinion.2-4 Those guidelines emphasize that the workup for acute excessive uterine bleeding depends upon a woman’s age, her medical and menstrual history, her risk factors for endometrial pathology, and her prior laboratory results.

    This patient is hemodynamically stable and does not need transfusion or hospitalization. It will not be possible to determine her formal diagnosis until the results of her tests are available.1-4 However, the challenge facing the clinician is that the patient needs treatment now to stop her excessive bleeding. 

    Hormonal management is first-line medical therapy for patients with acute abnormal uterine bleeding.4,5 However, there is no consistency among the hormonal regimens recommended and very little or no scientific evidence of efficacy for any of them. For example, medroxyprogesterone acetate (MPA) 10 mg a day for 10 days is often prescribed in emergency departments. Obstetrician-gynecologists themselves have developed different so-called oral contraceptive (OC) tapers with 4-3-2-1 OC tablets prescribed for consecutive days or 3-3-2-2-1 birth control pills to be taken on specified days.

    A recent European Consensus group offered 4 oral options for hormonal treatment of acute bleeding in women without underlying bleeding disorders: birth control pills with either 30 mcg or 50 mcg of ethinyl estradiol (EE) in combination with any progestin to be taken every 6 hours until bleeding stops (with a re-evaluation at 48 hours); norethindrone acetate 5 mg–10 mg every 4 hours; or MPA 10 mg every 4 hours (up to 80 mg per day). Each regimen had an accompanying taper protocol.5 Interestingly, the source for these options was an adolescent health protocol; no clinical studies were cited. 

     

    Anita L. Nelson, MD
    DR. NELSON is Professor of Obstetrics and Gynecology at the David Geffen School of Medicine at University of California, Los Angeles.

    4 Comments

    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • DARRINCUNNINGHAM
      Megestrol 20mg a day for 10 days. I find this to more efficacious than MPA. My patients have quicker decrease and cessation from bleeding.
    • Dr. jdiaz
      The correct handling of abnormal uterine bleeding may be of any type is to apply the mnemonic FIGO is PALM-COIN. Perform an ultrasound TV allows us to define whether this hypersecretory endometrium or is this proliferative or atrophic, we can guide the indication of medical treatment with progestin, estrogen, or combination of them, as well as add Hemostatic and nonsteroidal antiinflammatory drugs. Formulas are many and verifiable, but without proper guidance, treatments would only blind and pulling shots to see if you hit.
    • Dr. ghaber
      TYPO here should be 1.3 grams see attached Tranexamic acid James AH, Kouides PA, Abdul-Kadir R, Dietrich JE, Edlund M, Federici AB, et al. Evaluation and management of acute menorrhagia in women with and without underlying bleeding disorders: consensus from an international expert panel. Eur J Obstet Gynecol Reprod Biol 2011;158:124–34. 1.3 g orally§ or 10 mg/kg IV (maximum 600 mg/dose) Three times per day for 5 days (every 8 hours ) Contraindications include, but are not limited to, acquired impaired color vision and current thrombotic or thromboembolic disease. The agent should be used with caution in patients with a history of thrombosis (because of uncertain thrombotic risks), and concomitant administration of combined oral contraceptives needs to be carefully considered.
    • ulkeralizade700@------.com
      Hello Dr.Ghaber i am sorry My mother had abnormal uterine bleeding 4month ago doktor said pelvic is thin Prescribed her rigevidon-estrogen she gave a shcem 1tablet after 4hours 8hours then 12 and one tablet a day for21days .Tge doctor could stop the bleeding .But now my mother must stop the hormone teeraphy but she cant because when it is stoppend bleeding starts and continues till she takes hormon again. If you give some schem how to stop the hormon so glad for me.Doctor thank you a lot

    Poll

    Latest Tweets Follow