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    A link between ADHD and acetaminophen?



    A new study published in JAMA Pediatrics is raising concern about a potential association between use of acetaminophen in pregnancy and attention-deficit/hyperactivity disorder (ADHD) in offspring. But the Society for Maternal-Fetal Medicine (SMFM) is urging caution in interpretation and application of the findings, noting that the results relate to long-term use of acetaminophen, which is not typical in pregnancy, and association does not necessarily equal causation.

    Researchers from the University of California – Los Angeles and the University of Aarhus, in Denmark, studied 64,322 live-born children and their mothers, who were enrolled in the Danish National Birth Cohort from 1996 to 2002. Use of acetaminophen was assessed by performing 3 computer-assisted telephone interviews during pregnancy and in the 6 months after delivery. Parental reports of behavioral problems in children aged 7 years were identified using the Strengths and Difficulties Questionnaire, hyperkinetic (HKD) diagnoses were identified using the Danish National Hospital Registry or the Danish Psychiatric Central registry prior to 2011, and prescriptions for ADHD medications such as methylphenidate, in children were identified using the Danish Prescription Registry. Hazard ratios were estimated for receiving a diagnosis of HKD or using an ADHD medication; risk ratios were estimated for behavioral problems in children after prenatal exposure to acetaminophen.


    Miranda Hester
    Ms. Hester is Content Specialist with Contemporary OB/GYN and Contemporary Pediatrics.


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    • DaniDaniels
      Due to crippling shortages of raw materials, people having ADHD find it difficult to buy medicine to treat this kind of disorder. One of the most important medication shortages is that of Adderall, a popular medication for treating ADHD. For more information, click here.
    • [email protected]
      Various drugs are in severely short supply. Diminishing raw materials among other issues are causing several narcotics to not be produced in sufficient amounts. One of the most substantial drug shortages is that of Adderall, a well-known medication for managing Attention Deficit/Hyperactivity Disorder. Article resource: http://www.newsytype.com/14225-adderall-shortages/
    • Anonymous
      Please be aware that this is the second study finding an association between prenatal acetaminophen use and adverse neurodevelopment. Brandlistuen et al.2013 found in a large, well controlled, prospective cohort study that children exposed to long-term use of acetaminophen during pregnancy had substantially adverse developmental outcomes (autism phenotypes) at 3 years of age. http://www.ncbi.nlm.nih.gov/pubmed/24163279 Animal studies and ecological studies also support this association. Animal models: http://www.ncbi.nlm.nih.gov/pubmed/24361869 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534986/ http://www.ncbi.nlm.nih.gov/pubmed/24316461 http://www.ncbi.nlm.nih.gov/pubmed/21170329 http://www.ncbi.nlm.nih.gov/pubmed/23850354 http://www.ncbi.nlm.nih.gov/pubmed/21771276 Ecologic studies with biologic plausibility: http://www.ehjournal.net/content/pdf/1476-069X-12-41.pdf http://greatplainslaboratory.com/home/eng/Acetaminophen.asp


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