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    Is inadvertent HPV vaccination in pregnancy safe?

    Inadvertently receiving a dose of the quadrivalent human papillomavirus vaccine (4vHPV) may not be a cause for adverse pregnancy outcomes, according to a retrospective, observational cohort study presented at the 37th annual Pregnancy Meeting for the Society for Maternal-Fetal Medicine, in Las Vegas, Nevada.

    The researchers used administrative and healthcare data from the Vaccine Safety Datalink to look at a cohort of insured women aged 11 to 27 with singleton pregnancies that ended in a live birth between January 2007 and September 2013. Women who received the 4vHPV either during pregnancy or in the peri-conception period were classified as exposed. Controls were women with singleton pregnancies and a live birth during the same period who had received the 4vHPV vaccine in the 4 to 18 months prior to the start of pregnancy.

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    Risks of major structural birth defects, chorioamnionitis, small for gestational age birth, hypertensive disorders of pregnancy, gestational diabetes, and preterm birth (< 37 weeks’ gestation) were evaluated. Adjusted relative risk tied to receiving the 4vHPV vaccine pregnancy, the peri-conception period, and the risks for both periods combined were evaluated using a generalized estimating equation method.

    The researchers found 720 women who received the 4vHPV vaccine peri-conception and 638 who had received the vaccine during pregnancy with 8166 women with distal 4vHPV exposures. Overall, vaccination with 4vHPV during the peri-conception period and pregnancy was not associated with an increased risk of adverse obstetrical events such as gestational diabetes (peri-conception adjusted risk ratio [aRR]1.06, 95% confidence interval [CI] [1.02]; during pregnancy aRR .98 [.67 – 1.4]; combined period aRR 1.0 [.77 – 1.3]); birth outcomes like preterm birth (peri-conception aRR .93 [.69 – 1.2]; during pregnancy aRR .97 [.72 – 1.3]; combined period aRR .97 [.79 – 1.2]); and major structural birth defects (peri-conception aRR .94 [.49 – 1.8]; during pregnancy aRR .91 [.46 – 1.8]; combined period aRR .96 [.59 – 1.6]).

    The researchers concluded that inadvertent 4vHPV vaccine administration is not linked to adverse outcomes for either mother or infant. 

    Judith M. Orvos, ELS
    Judith M. Orvos, ELS, is a a BELS-certified medical writer and editor and an editorial consultant for Contemporary OB/GYN.
    Miranda Hester
    Ms. Hester is Content Specialist with Contemporary OB/GYN and Contemporary Pediatrics.

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