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    Infants also at risk from mothers' endometriosis


    The investigators also performed a subgroup analysis to assess risks in primiparous women with a singleton pregnancy and found the risk estimates for most outcomes were largely unchanged.
    Findings of another subgroup analysis showed complications risks were higher among women who underwent surgery for endometriosis prior to pregnancy. The investigators considered a surgical history a marker for severe endometriosis.

    The risks of most complications among women with endometriosis were reduced after adjustment for having had assisted reproductive techniques (ART), although they were still significantly increased. The investigators noted adjustment for ART also adjusted for severe endometriosis as well as for twin pregnancies.

    Discussing their study limitations, the investigators said that the control cohort may have included some women with undiagnosed endometriosis who were not captured in the national registers. However, such misclassification would likely lead to underestimation of the risk of complications in women with endometriosis.

    They also acknowledged that information on histological confirmation of endometriosis was not available.

    Although they considered a history of surgery for endometriosis as a surrogate for having more severe disease, they raised the possibility that surgery may also affect pregnancy outcomes by its effects on the intrauterine environment. Therefore, they called for further research investigating the effect of abdominal surgery.



    1. Berlac JF, Hartwell D, Skovlund CW, Langhoff-Roos J, Lidegaard Ø. Endometriosis increases the risk of obstetrical and neonatal complications. Acta Obstet Gynecol Scand. 2017 Feb 9. [Epub ahead of print]


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