/ /

  • linkedin
  • Increase Font
  • Sharebar

    Lower-Dose Estradiol Vaginal Cream Effectively Relieves Postmenopausal Dyspareunia



    Estradiol vs. Placebo Cream Results

    By the end of the study at 12 weeks, estradiol cream had significantly reduced severity of dyspareunia (mean change from baseline -1.5 ±1.0 vs. -1.2±0.9 for placebo). The statistically significant positive impact on dyspareunia severity was first seen by week 8. The active treatment also decreased vaginal pH and percentage of parabasal cells and increased percentage of superficial cells in comparison to placebo cream over 12 weeks. Estradiol cream significantly reduced the severity of vaginal dryness, but not vaginal/vulvar irritation and itching, compared to placebo at 12 weeks. Bleeding after intercourse was reduced in both groups and was statistically significant at P = 0.006 for estradiol cream at week 12. The effect on severity of dysuria could not be reported due to study design issues, but the investigators stated that there were “no discernable differences” between groups.

    In terms of safety, approximately half of subjects in both groups reported at least one adverse event (AE). Vulvovaginal mycotic infection was the most frequently reported treatment-emergent AE, affecting 6.9% of women in the estradiol group and 3.3% of women in the placebo group. Infection might be a consequence of estradiol-mediated lowering of vaginal pH, a change in composition of the vaginal microbiome, or a direct effect of estrogen on Candida species in the vagina, suggested the authors. Overall, the lower-dose estradiol cream was well-tolerated.


    Extended-Duration Trials Sought

    Vaginal administration of estradiol avoids appreciable systemic estrogen exposure, making it an attractive route of delivery to many patients who have concerns about hormone exposure and AEs related to estrogen use. It may also be an option for women who cannot tolerate higher doses of estrogen, according to the authors. However, few lower-dose estradiol trials have been conducted lasting longer than 12 weeks, and longer-term trials are required to further establish the safety of the formulation.

    Nancy Monson
    Nancy Monson is a freelance writer and certified health coach whose work has appeared in numerous major clinical and consumer print and ...


    You must be signed in to leave a comment. Registering is fast and free!

    All comments must follow the ModernMedicine Network community rules and terms of use, and will be moderated. ModernMedicine reserves the right to use the comments we receive, in whole or in part,in any medium. See also the Terms of Use, Privacy Policy and Community FAQ.

    • No comments available


    Latest Tweets Follow