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    Maternal obesity and the fetal brain

     

    Applications to patient care

    • Preconception counseling of obese and overweight women may be appropriate to discuss risks and to encourage weight loss and adoption of a healthy diet prior to pregnancy.

    • Maternal preconception lifestyle change and weight loss may also reduce the risk for preeclampsia and gestational/pregestational diabetes, which have also been associated with iatrogenic prematurity and an increased risk for ASD and other neurodevelopmental morbidity in offspring.

    • Evidence is insufficient to recommend routine omega-3 or omega-6 fatty acid supplementation in obese pregnant women to reduce the risk of offspring neurodevelopmental morbidity.

    • Evidence is insufficient to recommend routine use of metformin in obese pregnant women to reduce the risk of offspring neurodevelopmental morbidity.

     

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    Andrea G Edlow, MD, MSc
    Dr Edlow is an attending physician in the Division of Maternal-Fetal Medicine, Department of Ob-Gyn, Tufts Medical Center, Boston, ...
    Larissa H Mattei, BA
    Ms Mattei is a fourth-year medical student at Tufts University School of Medicine, Boston, Massachusetts.

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