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    News from ASRM


    Does Vitamin D influence pregnancy outcome?

    Results of a study supported by the National Institutes of Health (NIH) point to a positive role for maternal vitamin D levels in pregnancy outcomes. Presented at the 71st annual meeting of the American Society for Reproductive Medicine, the data point to a need for additional research about the role that the vitamin might play in gestation.

    Presented by NIH scientist Sunni Mumford, PhD, the findings are from a secondary analysis of the EAGer Trial, a multicenter, block-randomized, placebo-controlled trial. EAGer was designed to evaluate the effect of low-dose aspirin initiated before conception on pregnancy outcomes in women with a history of miscarriage.

    The 1228 women in EAGeR were aged 18 to 40 and all had experienced 1 or 2 miscarriages, had no history of infertility or gynecologic disorders, and intended to become pregnant again. At baseline, participants’ serum vitamin D levels were measured. Rates of pregnancy on spot urine clinic pregnancy tests, chemical pregnancy loss (positive hCG but not clinical evidence of pregnancy; n=56), and clinical pregnancy loss on ultrasound (n=133) then were tracked. 

    Investigators used generalized linear models adjusted for age, body mass index (BMI), and characteristics of the prior loss to estimate relative risk (RR) and 95% confidence intervals (CIs) for live birth and pregnancy loss. Inverse probability weights also were used to control for potential selection bias introduced by restricting to women who became pregnant.

    At baseline, 2% (17) of the women had deficient vitamin D levels (<30 nmol/L) and 12% (148) had inadequate levels (30-49 nmol/L). A positive, though clinically minimal, association was seen between vitamin D levels and live birth (RR 1.03, 95% CI 1.01, 1.05 per 10 nmol/L). Vitamins D levels also were inversely associated with pregnancy loss (RR 0.95, 95% CI 0.91, 1.00 per 10 nmol/L) and specifically clinical loss (RR 0.94, 95% CI 0.88, 1.00 per nmol/L). Discussing the findings at ASRM, Dr. Mumford noted that lower BMI, white race, higher education, and having a blood draw in the summer all were characteristics in the women that were associated with adequate vitamin D levels.


    Mumford SL, Matyas RA, Silver RM, et al. Vitamin D and pregnancy loss and live birth: results from the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial. O-139. Presented Tuesday, October 20, 2015 at 11:15 a.m.


    Judith M. Orvos, ELS
    Judith M. Orvos, ELS, is a a BELS-certified medical writer and editor and an editorial consultant for Contemporary OB/GYN.


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